IgA Nephropathy is a relatively common kidney disease. It affects millions of
people worldwide. It is a disease that affects the filters, or glomeruli, of the
kidneys. IgA is characterized by the hematuria it causes, which just means blood
in the urine. This blood may be visible to the naked eye or only seen under a
microscope. Over time this disease can damage the kidney’s ability to clean the
blood properly. Most people with this disease lose kidney function very slowly,
or not at all.
IgA Nephropathy is named for the deposits of IgA that can be seen stuck in
the kidney filters when viewed under a microscope. IgA is an immunoglobulin- a
normal component of a healthy immune system. These components normally attach
themselves to infection in the body and trigger the immune response. This works
to eliminate the infection. In this disease, a defective form of IgA gets bound
to another IgA molecule instead of an infection. This forms an immune complex.
This immune complex can become stuck in the kidney. Here it activates the immune
system just like it would if it were fighting off infection. The immune system
activation causes swelling and damage to the kidney itself. This disease may be
suspected from certain symptoms (see below). However, a diagnosis of IgA
Nephropathy requires a kidney biopsy. The sample of kidney can then be viewed
under a microscope and the diagnosis confirmed.
This disease is common, but there is no single treatment about which all
doctors agree. This is in part because of the disease tends to progress very
slowly, if at all. Many of the drugs that could be used in treatment can be very
harmful.
It is generally accepted that blood pressure control and limiting the amount
of protein in the urine are of primary importance. Both of these goals can often
be accomplished with the use of two types of blood pressure medications.
ACE-inhibitors (angiotensin converting enzyme inhibitors) and ARBs (angiotensin
II receptor blockers) both help to reduce blood pressure. Another commonly used
agent is Fish Oil. Studies do not agree on its true benefit. However, its lack
of serious side-effects leads many doctors to recommend it.
This disease is essentially an over-activation of the immune system.
Therefore, many immunosuppressive drugs have been tried with varying success.
The most widely used are steroids, given either through a needle, by mouth, or
both for at least 6 months.
IgA often progresses slowly. Doctors may simply follow some patients with
normal renal function and minimal protein in the urine without starting any
therapy at all. It is the disease’s generally slow progression that has made it
difficult for doctors to decide on the one “best” treatment.
Micro-Chinese Medicine Osotherapy is a external application it takes effects
on expending blood vessels and speed up blood circulation, so as to improve the
kidney function. If you want to know more, you can send email to kidneyhospitalabroad@hotmail.com
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